László Nagy, M.D., Ph.D., Dr.habil., MHAS - PDF

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Curriculum Vitae László Nagy, M.D., Ph.D., Dr.habil., MHAS Personal details: Office address: Department of Biochemistry and Molecular Biology Research Center for Molecular Medicine Medical and Health Science

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Curriculum Vitae László Nagy, M.D., Ph.D., Dr.habil., MHAS Personal details: Office address: Department of Biochemistry and Molecular Biology Research Center for Molecular Medicine Medical and Health Science Center University of Debrecen, Hungary Life Science Building, Egyetem tér 1. Debrecen, Hungary H-4010 phone: fax: Web: Citizenship: Hungarian Degrees: Member of the Hungarian Academy of Sciences (2007) Dr. habil. (Habilitation) University of Debrecen, Basic Medical Sciences [6/2006] (2006) Doctor of the Hungarian Academy of Sciences (D.Sc.) Biological Sciences (Biochemistry and Molecular Biology) [4.481/2005] (2005) Doctor of Philosophy (Ph.D.) (Summa cum laude) Medical Sciences (Cell and Molecular Biology), University Medical School of Debrecen, Hungary [G /1995] (1995) László Nagy, M.D., Ph.D., D.Sc., Dr. habil., MHAS, January 2012 Medical Doctor (M.D.) (Summa cum laude) University Medical School of Debrecen, Hungary [35-117/91] (1991) Languages: English (State Exam, Advanced Level A #019455, 2000) Russian (State Exam, Intermediate Level # A /1987) Professional Appointments: Present appointments: Primary appointments: Professor of Biochemistry and Molecular Biology, Department of Biochemistry and Molecular Biology, University of Debrecen, Hungary (September 1, 2006-) Head of Debrecen Clinical Genomics Center (July 1, 2000-) Secondary appointments: Fulbright Scholar Visiting Scientist, The Salk Institute for Biological Studies ( ) International Research Scholar of the Howard Hughes Medical Institute ( ) Past appointments: Wellcome Trust International Senior Research Fellow ( ) Adjunct Professor of Pharmacology and Physiology Department of Integrative Biology Pharmacology and Physiology University of Texas-Houston, Medical School, Houston Texas, USA (September 1, August 31, 2010) Associate Professor of Biochemistry and Molecular Biology, Department of Biochemistry and Molecular Biology, University of Debrecen, Hungary (July 1, August 31, 2006) Young Investigator of the European Molecular Biology Organization (EMBO) (July 1, June 30, 2004) * Assistant Professor of Biochemistry and Molecular Biology, Department of Biochemistry and Molecular Biology, University of Debrecen, Hungary (October 1, June 30, 2000) 2 László Nagy, M.D., Ph.D., D.Sc., Dr. habil., MHAS January, 2012 Postdoctoral Associate, Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, USA ( ) Special Fellow of the Leukemia Society of America ( ) Postdoctoral Fellow of the Howard Hughes Medical Institute ( ) Advisor: Ronald M. Evans Ph.D. Instructor in Biochemistry and Molecular Biology, Department of Biochemistry and Molecular Biology, University medical School of Debrecen, Hungary (April September ) Postdoctoral Fellow, Department of Pharmacology, University of Texas, Houston, Medical School, USA, ( ) Advisor: Peter J.A. Davies M.D., Ph.D. Research Fellow of the Hungarian Academy of Sciences, Department of Biochemistry, University Medical School, Debrecen, Hungary. ( ) Advisor: Laszlo Fesus M.D., Ph.D. * First independent position Education (graduate and postgraduate): Ph.D. Student, in Medical Sciences (cell and molecular biology), University Medical School, Debrecen, Hungary ( ) Advisors: Dr Peter J.A. Davies, University of Texas-Houston and Dr László Fésüs, University Medical School of Debrecen Medical Student, University Medical School, Debrecen, Hungary (including one year internship in 1991) ( ) High School Student, Tóth Árpád Gimnázium, Debrecen, Hungary ( ) Awards and Honors: Pro Scientia Gold Medal for Outstanding Scientific Achievements presented by the President of the Hungarian Academy of Sciences (1989) Outstanding Tutor in Biology University Medical School of Debrecen (1989) Weszprémi-Prize for Outstanding Academic and Scientific Activity presented by the Rector of the University Medical School of Debrecen (1991) Special Fellow of the Leukemia Society of America) ( ) Cheryl Whitlock/Pathology Prize, Stanford University (1998) Boehringer Ingelheim Research Award (1999) Széchenyi Professorship ( ) Ranked as #5 scientist in 1999 based on the number of highly cited, Hot papers published in (Institute for Scientific Information Hot papers Database) 3 László Nagy, M.D., Ph.D., D.Sc., Dr. habil., MHAS, January 2012 Howard Hughes Medical Institute International Research Scholar ( ) EMBO Young Investigator ( ) Szechenyi Istvan Fellowship ( ) Wellcome Trust International Senior Research Fellow ( ) EMBO Member (2007) ESCI Award for Excellence in Biomedical Investigation (2008) Fulbright Scholar ( ) Memberships in professional societies: Hungarian Biochemical Society, Member since 1989 Society of Pro Scientia Gold Medal Laureates, Member since 1995 Endocrine Society (USA), Active Member since 2002 European Macrophage and Dendritic Cell Society, Member since 2002 American Society of Biochemistry and Molecular Biology, Member since 2003 Hungarian Society for Bioinformatics, Founding member, executive committee member American Association of Immunologists, member since 2011 Advisory functions: BioSystems International SAS, Scientific advisor ( ) Cell therapy Unit, University of Debrecen Member of the Scientific Advisory Board (2004-) Gerson Lerhman Group Councils, member since 2006 UDGenoMed, Ltd., Chief Scientific Officer (2007-) Gedeon Richter, Inc., Member of the Scientific Advisory Board (2008-) Member of the International Advisory Board of the 10 th Symposiom on Dendritic cells DC2008 (Kobe, Japan) International Society of Dendritic Cell and Vaccine Research, Advisory Committee member (2010-) Institute of Genetics, HAS BRC, Szeged Scientific Advisory Board, member (2010-) Refereeing and editorial functions: EMBO Reports, Member of the Advisory Editorial Board, FEBS Letters, Editor FEBS OpenBio, Founding Editor European Journal of Clinical Investigation, Member of the Editorial Board, PPAR Research, Advisory Editor Cell Death and Disease, Member of the Advisory Editorial Board (2010-) Encyclopedia of Life Sciences, Biochemistry, Advisory Editorial Board Member (2010-) Ad hoc reviewer for the following journals and organizations: 4 László Nagy, M.D., Ph.D., D.Sc., Dr. habil., MHAS January, 2012 Journals: Arthritis and Rheumatism Atherosclerosis, Thrombosis and Vascular Biology Biochemical Pharmacology BBA Biomolecular Concepts Blood BMC Medical Genomics Chemistry and Biology Circulation Cell Death and Differentiation Cellular Reprogramming Diabetologia Drug Discovery Today EMBO Journal EMBO Reports European Journal of Immunology Immunity International Journal of Biochemistry and Molecular Biology International Journal of Cancer International Immunology Journal of Biological Chemistry Journal of Clinical Investigations Journal of Immunology Journal of Leukocyte Biology Leukemia Molecular and Cellular Biology Molecular and Cellular Endocrinology Molecular Endocrinology Molecular Nutrition and Food Research Molecular Pharmacology Nature Nature Medicine Physiology Proceedings of the National Academy of Sciences of the USA PLoSONE Science Science Signaling WIREs Systems Biology and Medicine Research funding organizations: - Boehringer Ingelheim Funds (Germany) - Commission of the European Union (evaluator, reviewer, rapporteaur) - The Wellcome Trust (UK) - FWO Belgium - European Molecular Biology Organization (EMBO) - Netherlands Organization for Scientific Research (NWO) (The Netherlands) - Hungarian Scientific Research Fund (OTKA) - National Science Foundation (USA) - Association for International Cancer Research (UK) 5 László Nagy, M.D., Ph.D., D.Sc., Dr. habil., MHAS, January Semmelweis University, Hungary - Spanish Ministry of Health (Spain) - Hungarian Academy of Sciences (Bolyai Fellowship Committee) - Luxembourg National Research Fund (Luxembourg) - Austrian Science Fund (FWF) (Austria) - Swiss Federal Institute of Technology Zurich (ETH) (Switzerland) - Science Foundation of Ireland - National Institutes of Health (intramural research) (USA) Ongoing research support Hungarian Scientific Research Fund (OTKA) (K100196) A novel mouse model for the study of PPARγ deficiency ( ) FP7-REGPOT / MOLMEDREX Development of the Research Center for Molecular Medicine of the University of Debrecen, Medical and Health Science Center ( ) Hungarian Scientific Research Fund (OTKA) (NK72730) Decoding nuclear hormone receptor activity using chromatin immunoprecipitation in human primary immune cells ( ) Completed: International Research Scholarship of the Howard Hughes Medical Institute (USA) PPARγ a lipid activated transcription factor at the crossroad of lipid metabolism and inflammation # ( ) International Research Scholarship of the Howard Hughes Medical Institute (USA) Role of a lipid activated transcription factor, PPARgamma in the innate responses of macrophages during pathogen infection # ( ) TAMOP-4.2.2/08/1 IKUT Stem cell and gene therapy research center at the University of Debrecen, Medical and Health Science Center ( ) Wellcome Trust International Senior Research Fellowship Role of RXR heterodimers in macrophage differentiation and function # ( ) European Union Framework Program 5 Nutriceptors Research Training Network No 6 László Nagy, M.D., Ph.D., D.Sc., Dr. habil., MHAS January, 2012 ( ) Practical Course on Advanced Methods on Gene Expression Analysis Howard Hughes Medical Institute (USA) ( ) International Research Scholarship of the Howard Hughes Medical Institute (USA) # Role of PPARγ in normal monocyte-macrophage cell function and in diseases ( ) Biotechnology 2002 (Hungarian Ministry of Education) New molecular methods for the detection and monitoring of metabolic diseases: the role of nuclear receptors Young Investigator Award of The Human Frontier Science Program Crosstalk between PPAR and LXR in the control of lipid metabolism RGY021/2001- M ( ) Hungarian Scientific Research Fund (OTKA) T Role of PPARg:RXR heterodimers in myeloid cell differentiation and function ( ) European Union Framework Program 5 EU-NUC-REC-NET Research Training Network European network to study the regulation of key metabolic processes by nuclear receptors No HPRN-CT ( ) European Molecular Biology Organization (EMBO) Young Investigator Award #0246 ( ) Hungarian Higher Education Research Fund (FKFP) 0208/2001 Role for PPARg and LXR in the biological effects of modified LDL ( ) Fogarty International Research Collaboration Award (FIRCA) 5 RO3 TW Chromatin activation in retinoid-induced apoptosis US collaborator: Dr Peter J.A. Davies (University of Texas-Houston, Medical School) ( ) Royal Society (UK) Hormonal regulation of nuclear receptor co-repressor interactions (UK project leader: Dr John W.R.Schwabe MRC-LMB, Cambridge) ( ) Boehringer Ingelheim Research Award Molecular mechanisms of nuclear receptor action in health and disease ( ) 7 László Nagy, M.D., Ph.D., D.Sc., Dr. habil., MHAS, January 2012 Egészségügyi Tudományos Tanács (ETT) (Hungarian Ministry of Health) T /99 The role of the lipid activated transcription factor PPAR in the pathogenesis of atherosclerosis ( ) Leukemia Society of America Special Fellow Award ( ) Postdoctoral Fellowship of the Howard Hughes Medical Institute ( , 12 months) Postdoctoral Fellowship of the University of Texas-Houston, Medical School (1992, 6 months) FASEB Travel Fellowship for the 1992 Summer Conference on Retinoids Saxtons River, Vermont June Medical Student Grant (Pro Cultura Foundation) Generation of tissue transglutaminase null mutant cell lines with homolog recombination (1992) Research Studentship (3 months) Dept. of Pharmacology, Univ. of Texas HSC at Houston, USA 1989, (Soros Foundation). FEBS Youth Travel Fellowship FEBS International Summer School on the Molecular Genetics of Differentiation, West-Berlin 1989 Research and development activity (collaborations with industry): Ongoing: SCHIZO-08 Biobank based biomarker discovery in schizophrenia NKFP ( ) Completed: Biosystems International SAS, France Comprehensive pilot and biomarker early validation studies for COPD GPCR target and biomarker discovery ( ) Pfizer Global Research, Sandwitch, UK Discovery and validation of biomarkers and drug targets for COPD: a clinical genomics, proteomics and genetics collaboration with the University of Debrecen. ( ) Richter Gedeon Ltd, Hungary Global gene expression analysis on rat liver ( ) 8 László Nagy, M.D., Ph.D., D.Sc., Dr. habil., MHAS January, 2012 Pfizer Global Research, Fresnes Laboratories, France Identification of disease relevant target and biomarker candidates by comprehensive interrogation of the genome and proteome in COPD ( ) N-GENE Research and Development Ltd, Budapest, Hungary Analysis of GBP-15 in PPAR regulated processes (2004) Biorex Rt., Hungary Development of quantitative PCR assays ( ) 9 László Nagy, M.D., Ph.D., D.Sc., Dr. habil., MHAS, January 2012 Publications: Retinoic Acid Receptor Transcripts in Human Umbilical Vein Endothelial Cells Fesus, L., Nagy,L., Basilion,J. and Davies,P.J.A. Biochem. Biophys. Res. Comm. 179:32-38 (1991) Tissue Transglutaminase: an effector in physiologic cell death Nagy,L., Thomazy,V. and Davies,P.J.A. Cancer Bulletin 46: (1994) INVITED REVIEW Activation of Retinoid X Receptors Induces Apoptosis in HL-60 Cell Lines Nagy, L., Thomazy, V.A., Shipley, G.L., Fesus, L., Lamph, W., Heyman, R.A., Chandraratna, R.A.S. and Davies, P.J.A. Molecular and Cellular Biology 15: (1995) Identification and Characterization of a Versatile Retinoid Response Element (Retinoic Acid Response Element/Retinoid X Receptor Response Element) in the Mouse Tissue Transglutaminase Gene Promoter Nagy, L., Saydak, M.M., Shipley, N., Lu, S., Basilion, J.P., Yan, Z-H., Syka, P., Chandraratna, RA.S., Stein, J.P., Heyman, R.A. and Davies, P.J.A. Journal of Biological Chemistry 271 (8): (1996) 5. Retinoid-regulated Expression of BCL-2 and Tissue Transglutaminase During Differentiation and Apoptosis of Human Myeloid Leukemia (HL-60) Cells Nagy, L., Thomazy, V.A., Heyman, R.A., Chandraratna, R.A.S. and Davies, P.J.A. Leukemia Research 20 (6): (1996) 6. Retinoic acid induction of the tissue transglutaminase promoter is mediated by a novel response element Yan, H- Z., Noonan, S., Nagy, L., Davies, P.J.A. and Stein, J.P. Molecular and Cellular Endocrinology 120: (1996) Nuclear receptor repression mediated by a complex containing SMRT, msin3a and histone deacetylase Nagy, L., Kao, H-Y., Chakravarti, D., Lin, R.J., Hassig, C.A., Ayer, D.E., Schreiber, S.L. and Evans, R.M. Cell 89 (3): (1997) 8. Lack of induction of tissue transglutaminase but activation of the preexisting enzyme in c-myc-induced apoptosis of CHO cells Balajthy, Z., Kedei, N., Nagy, L., Davies P.J.A and Fesus., L. Biochem. Biophys. Res. Comm. 236: (1997) 10 László Nagy, M.D., Ph.D., D.Sc., Dr. habil., MHAS January, Nuclear receptor co-activator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300 Chen, H., Lin, R., Schiltz, L., Chakravarti, D., Nash, A., Nagy, L., Privalsky, M.L., Nakatani, Y. and Evans, R.M. Cell 90 (3): (1997) 10. The promoter of the mouse tissue transglutaminase gene directs tissue-specific, retinoid regulated and apoptosis linked expression Nagy, L., Thomazy, A.V., Saydak, M.M., Stein, J.P. and Davies, P.J.A. Cell Death and Differentiation 4 (7): (1997) TNF-a modulates expression of the tissue transglutaminase gene in liver cells Kuncio, GS., Tsyganskaya, M., Zhu, J,, Liu, S-L., Nagy, L., Thomazy, VA., Davies, PJA. And Zern, MA American Journal of Physiology 37(2): G (1998) 12. Retinoid-induced apoptosis in normal and neoplastic tissues Nagy, L., Thomazy,V.A., Heyman, R.A and Davies, P.J.A. Cell Death and Differentiation 5(1): (1998) INVITED REVIEW 13. A transgenic mouse model for the study of apoptosis during limb development Nagy, L., Thomazy, V. A, and Davies, P.J.A. Cell Death and Differentiation 5(1): 126 (1998) INVITED REVIEW 14. Role of the histone deacetylase complex in Acute Promyelocytic Leukemia Lin, J.R., Nagy, L., Satoshi, I., Shao, W., Miller, W., and Evans, R.M. Nature 391: (1998) 15. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ Nagy, L., Tontonoz, P., Alvarez, JGA., Chen, H. and Evans, RM. Cell 93(2): (1998) 16. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL Tontonoz, P.*, Nagy, L.*, Alvarez, JGA., Thomazy, VA. and Evans, RM. Cell 93(2): (1998) * joint first authors Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP- 7 expression in mouse autopods Dupe, V., Ghyselinck, N.B., Thomazy, V., Nagy, L., Davies, P.J.A., Chambon, P. and Mark, M. Developmental Biology 208:30-43 (1999) 18. Regulation of macrophage gene expression by PPARγ: implications for cardiovascular disease Tontonoz, P and Nagy, L. Current Opinion in Lipidology 10(6): (1999) INVITED REVIEW 11 László Nagy, M.D., Ph.D., D.Sc., Dr. habil., MHAS, January Molecular mechanisms of nuclear hormone receptor action in health and disease Nagy, L. B.I.F. Futura (Boehringer Ingelheim Funds) 14: (1999) INVITED REVIEW 20. Mechanism of co-repressor binding and release from nuclear hormone receptors Nagy, L., Kao H-Y., Love, JD,, Li, C., Banayo, E., Gooch, JT., Chatterjee, VKK, Evans, RM and Schwabe, JWR Genes and Development 13(24): (1999) Transcriptional repression by nuclear receptors: mechanisms and role in disease Love, J.D., Gooch, J.T., Nagy, L., Chatterjee, V.K.K. And Schwabe, J.W.R Biochem. Soc. Trans. 28: (2000) INVITED REVIEW 22. A role for PPARa in oxidized phospholipid induced synthesis of MCP-1 and IL-8 by endothelial cells Lee, H, Shi, W, Tontonoz, P, Wang, S, Subbanagounder, G., Hedrick, L., Hama, S., Borromeo,C., Evans, RM., Berliner, JA and Nagy, L. Circulation Research 87: (2000) 23. Divergent signalingpathways regulate the promoter of tissue transglutaminase Szegezdi, E, Szondy, Z, Nagy, L., Nemes, Z., Friis, RR., Davies, PJA and Fesus, L. Cell Death and Differentiation 7(12): (2000) PPARγ dependent and independent effects on macrophage gene expression in lipid metabolism and inflammation Chawla, A., Barak, Y., Nagy, L., Liao, D. Tontonoz, P., and Evans, RM Nature Medicine 7(1):48-53 (2001) 25. Tissue specific effects of RXR and PPAR-gamma ligands on metabolic gene expression in diabetic rodents Ahuja, HS, Crombie, DL, Boehm, M,Leibowitz, MD, Heyman, RA, Depre, C, Nagy, L., Tontonoz, P and Davies, P.J.A. Molecular Pharmacology 59 (4) (2001) 26. A PPARγ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis Chawla, A, Boisvert, W.A., Lee, C-H., Laffitte, B., Barak, Y., Joseph, S.B., Nagy, L., Liao, D., Edwards, P.A., Curtiss, L.K., Evans, R.M., and Tontonoz, P. Molecular Cell 7: (2001) 12 László Nagy, M.D., Ph.D., D.Sc., Dr. habil., MHAS January, The structural basis for the specificity of retinoid-x-receptor selective agonists: new insights into the role of helix H12. Love, J.D., Gooch, J.T., Benko, S., Nagy, L., Chatterjee, V.K.K., Evans,, R.M. and Schwabe, J.W.R. Journal of Biological Chemistry 277(13): (2002) 28. Lipid sensors in atherosclerosis: The role of nuclear hormone receptors in disease progression Szanto, A and Nagy, L. B.I.F. Futura (Boehringer Ingelheim Funds) 17: (2002) INVITED REVIEW The retinoid X receptor and its ligands: versatile regulators of metabolic function, cell differentiation and cell death Ahuja, A.S., Szanto, A., Nagy, L. and Davies, P.J.A. Journal of Biological Regulators and Homeostatic Agents 17:29-45 (2003) INVITED REVIEW 30. Molecular determinants of the balance between co-repressor and co-activator recruitment to the retinoic acid receptor Benko S., Love, J.D., Beládi, M., Schwabe, J.W.R. and Nagy, L., Journal of Biological Chemistry 278: (2003) The mechanism of nuclear receptor molecular switch Nagy, L. and Schwabe J.W.R. Trends in Biochemical Sciences 29(6): (2004) 32. Activation of PPARγ specifies a dendritic cell subtype capable of enhanced inducti
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