Committee. President PGDIS Reneé Martin, Canada. Honorary President Robert G Edwards, UK. Congress President Nicolas H Zech, Austria - PDF

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Committee President PGDIS Reneé Martin, Canada Honorary President Robert G Edwards, UK Congress President Nicolas H Zech, Austria Scientific Committee Alan H Handyside, UK Nicolas H Zech, Austria Herbert

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Committee President PGDIS Reneé Martin, Canada Honorary President Robert G Edwards, UK Congress President Nicolas H Zech, Austria Scientific Committee Alan H Handyside, UK Nicolas H Zech, Austria Herbert Zech, Austria Tina Bucholz, Germany Dimitra Christopikou, Greece David Cram, Australia Gabrielle Candolle, Switzerland Francesco Fiorentino,Italy Renee Frydman, France Darren Griffin, UK Samir Hamamah, France Joyce Harper, UK Gary Harton, USA Anver Kuliev, USA Stuart Lavery, UK Cristina Magli, Italy Markus Montag, Germany Santiago Munne, USA Sjoerd Repping, The Netherlands Zev Rosenwaks, USA Carmen Rubio, Spain Andreas Schmutzler, Germany Joel L Simpson, USA Alan Thornhill, UK Nathan Treff, USA Ilan Tur-Kaspa, USA Joris Vermeesch, Belgium Katerina Vesela, Czech Republic Dagan Wells, UK Leeanda Wilton, Australia Kangpu Xu, USA 2 Welcome Dear Colleagues! On behalf of the Preimplantation Genetic Diagnosis International Society (PGDIS) we take great pleasure in inviting you to the 11 th International Conference, which is held biannually, and this year is in Bregenz, Austria. The PGD Conference will address a much wider range of topics than PGD, as the recent developments in related areas may soon move PGD from a research tool to the basic procedure in reproductive medicine and genetic practices. First of all, the recent application of microarray technology and next generation sequencing may clearly improve the accuracy of PGD for genetic and chromosomal disorders, so array-cgh, SNP arrays, genome wide analysis and next generation sequencing for single cell analysis will be one of the major topics of the Conference. In addition some related theoretical issues, such as molecular aspects of meiosis and cell fate in the preimplantation embryo will be also addressed. On the other hand, because of increasing importance of clinical aspects of PGD, a number of Workshops will be organized on advance topics in clinical PGD, as well as a few debates on controversial issues in PGD, such as the optimal stage for performing biopsy procedures and reproductive outcome of preimplantation aneuploidy testing, prior to and after the application of 24-chromosome analysis, currently performed in a few dozens of thousands of cycles. As PGD is still closely related to prenatal diagnosis practices, the developments in preconception screening by next generation sequencing, non-invasive approaches and impact of new technologies on prenatal diagnosis will be also reviewed. We are honored to have international experts and pioneers in the field of preimplantation and prenatal genetic testing as speakers in Bregenz, the conference venue. Bregenz and its Congress Centre are ideally suited to provide an atmosphere for creativity and new ideas. We look forward to welcoming you on the shores of Lake Constance in May Nicolas H Zech Congress President Alan H Handyside Chairman, Scientific Committee 3 Dedication The meeting this year is dedicated to the late Yury Verlinsky, one of the outstanding pioneers of PGD and a co-founder of PGDIS, and Sir Robert Edwards, who, amongst many other achievements, with Patrick Steptoe pioneered in vitro fertilisation (IVF) and was finally recognised by the award of the Nobel Prize for Medicine and Physiology in October, 2010, and a knighthood in the Queen s birthday honours in June, Dr. Yury Verlinsky (09/01/ /16/2009) obtained his PhD in Cytogenetics and Embryology from Kharkov University. He was among the first in the world, and the first in the United States to introduce chorionic villus sampling (CVS) for prenatal diagnosis in the early 1980s. In 1990 he pioneered the polar body testing for preimplantation genetic diagnosis, which became one of the two major approaches for preimplantation diagnosis. He also developed the methods for karyotyping of second polar body and individual blastomeres for preimplantation diagnosis of translocations. Sir Robert Geoffrey Edwards (born 09/27/1925) studied at the Institute of Animal Genetics, University of Edinburgh. In 1955 he received his Ph.D. In about 1960 Edwards started to study human fertilisation, and he continued his work at Cambridge, laying the groundwork for his later success. In 1968 he was able to achieve fertilisation of a human egg in the laboratory and started to collaborate with Patrick Steptoe, a gynecologic surgeon from Oldham. Edwards developed human culture media to allow the fertilisation and early embryo culture, while Steptoe utilized laparoscopy to recover ovocytes from patients with tubal infertility. The birth of Louise Brown, the world s first test-tube baby, on 25 July 1978 made medical history: in vitro fertilisation meant a new way to help infertile couples who formerly had no possibility of having a baby. 4 General Information Conference venue Bregenzer Festspiel- und Kongresshaus GmbH (Congress & Festival Center Bregenz) Platz der Wiener Symphoniker Bregenz, Österreich Pre-courses Hotel Mercure Bregenz City (vis-à-vis Congress & Festival Center Bregenz) Platz der Wiener Symphoniker Bregenz, Österreich Wednesday, May 16: 07:30 15:00 Conference registration Conference registration will be open at the Congress & Festival Center Bregenz on: Wednesday, May 16: 17:00 19:00 Thursday, May 17: 19:00 18:30 Friday, May 18: 07:00 19:00 Saturday, May 19: 08:00 15:00 Upon arrival, all participants should check in at the registration desk to receive conference documents and identification badges. Official language The official language is English. Speakers Please bring your presentation-data at least 1 hour before the start of your session to the registration desk to be uploaded. Posters Poster sessions will be held as open discussions; soft drinks and snacks will be available. Poster panels are cm (B H). Fixing supplies will be available at the registration desk. Each poster will be assigned an identification number which will be indicated on the poster panel. Time for poster assemblage: Wednesday, May 16: :00 Thursday, May 17: 08:00 10:30 Time for poster removal: Saturday, May 19: 12:00 5 Posters left behind after the event will not be returned to the speaker, so please make sure to take your poster with you upon leaving. Abstract book Abstracts selected for oral communication and posters presented during the symposium will be published in a supplementary issue of Reproductive Biomedicine Online and distributed along with the other conference material. CEM credit Approval of the pre-congress courses and of the annual meeting program for continuing medical education (CME) credits will be applied. Registration fees All registration fees are in EURO. Student or para- Student or para- Member Non-member medical member medical non-member of PGDIS of PGDIS of PGDIS of PGDIS Before April 30, After April 30, Day registration Pre-course The registration fee for the annual meeting includes: admission to all scientific sessions and the exhibition lunch and coffee breaks final program and abstract book a certificate of attendance congress dinner (May 18, 2012) The registration fee for the pre-congress courses includes: admission to one or two specific courses as selected lunch and coffee breaks on the day of the pre-congress courses Important notice! Student applies to undergraduate, graduate and medical students, residents and post-doctoral research trainees. Paramedical applies to support personnel such as nurses/midwives, laboratory assistents, clinical embryologists. Registrations as student or paramedical must be accompanied by a letter from the head of the department confirming their status. Letters have to be sent to the PGDIS central office 2012.com). Registrations without accompanying letter will not be accepted and subsequently low fees will not apply. Membership fees only apply to members of PGDIS. Please note that although non-members can apply for membership prior to meeting registration, membership application processing usually takes up to one week. 6 Cancellation: Only cancellations made in writing ( ) at least 30 working days prior to the event will be reimbursed after deduction of a EURO 50. handling fee. Registration fee for accompanying person includes: Gala dinner Day registration includes: admission to all scientific sessions during the selected day of attendance admission to poster and technical exhibition during the selected day of attendance congress bag with congress materials and abstract book coffee breaks and lunch certificate of attendance Climate Average temperature in Bregenz in May is in the range of C Social program PGDIS Bregenz 2012 Gala dinner Friday, 18 May18, 2012, 19:30 Bregenz Festspielhaus Werkstattbühne Accommodation Bodensee-Vorarlberg Tourismus Römerstraße 2, 4. Stock 6900 Bregenz, Österreich Tel: +43 (0) Fax: +43 (0) How to get to Bregenz By Plane: Next International Airport: Zurich Trains from Zurich Airport to Bregenz/Bregenz to Zurich Airport Departure Train Arrival Departure Train Arrival Zürich Airport number Bregenz Duration Bregenz number Zürich Airport Duration 07:28 EC :53 1:25 h 10:06 EC :32 1:26 h 09:28 EC :53 1:25 h 15:06 EC :32 1:26 h 13:28 EC :53 1:25 h 19:06 EC :32 1:26 h 18:28 EC :53 1:25 h 7 By Train: The Congress & Festival Center Bregenz is situated right next to the central train station of Bregenz. It has ICE train connection and it is also the main bus terminal. By Car: Visitors arriving by car will find several large parking facilities in Bregenz. Coming from Switzerland: customs office at Höchst (Austria) then turn right at the first junction continue on the B 202 via Fußach and Hard in the direction of Bregenz Zentrum (Rheinstraße) straight ahead until the sign Festspielhaus , then turn right over the bridge Coming from Germany: Autobahn A 14 Pfänder Tunnel after the tunnel take the first exit on the right to Bregenz City Tunnel after the tunnel, bear right (Rheinstraße) after approx. 400 m turn right over the bridge (sign Festspielhaus ) Please notice: road tax vignettes are required on Austrian motorways! For a hassle-free journey on the Autobahn buy a Korridor-Vignette windshield sticker. This is especially for the section of the Autobahn in Austria between the German and Swiss borders. It is valid for 24 hours and costs only 2 EURO each way. 8 Program at a Glance Wednesday May 16, :00 10:00 Registration for pre-congress workshops 17:00 19:00 Registration for PGDIS 2012 in the Congress Center 08:30 18:00 Pre-congress workshops and meetings (Hotel Mercure) 18:00 20:00 PGDIS board meeting Thursday May 17, :15 Introduction and welcome 08:30 10:00 Plenary session (1) New developments in preconception testing and prenatal diagnosis 10:00 10:30 Coffee 10:30 12:30 Session (1) The polar bodies of the oocyte: insights into meiosis and maternal genetic defects 12:30 14:00 Lunch 14:00 16:00 Invited oral communications (1) 16:00 16:30 Tea 16:30 18:30 Advanced topics in clinical PGD (1) 18:30 19:30 Poster session (1) 20:30 Invited speakers dinner Friday May 18, :30 10:00 Plenary session (2) From zygote to blastocyst: the establishment of cell lineages 10:00 10:30 Coffee 10:30 12:30 Session (2) The cleavage and blastocyst stage embryo: the evolving genome 12:30 14:00 Lunch 14:00 16:00 Invited oral communications (2) 16:00 16:30 Tea 16:30 18:00 Advanced topics in clinical PGD (2) 18:00 18:30 PGDIS annual general meeting 18:30 19:00 Poster session (2) 19:30 Gala conference dinner Saturday May 19, :30 10:00 Plenary session (3) The challenge of genomic technologies and next generation sequencing 10:00 10:30 Coffee 10:30 12:30 Session (3) Genome wide analysis for PGD 12:30 Closing remarks 13:00 14:00 Lunch 9 Wednesday May 16, 2012 (Hotel Mercure) 08:00 10:00 Registration for pre-congress workshops 17:00 19:00 Registration for PGDIS 2012 in the Congress Center Pre-congress workshops and meetings (Coffee and lunch provided) 08:30 12:00 1. Array CGH (organised by Tony Gordon, BlueGnome Ltd) Setting up a laboratory for PGS equipment and logistic requirements Which sample to biopsy and practical considerations for running PGS acgh software analysis Reciprocal translocations/robertsonian translocations/ inversions what imbalances can acgh be used to detect in PGS? An introduction to karyomapping 08:30 12:00 2. Gamete and embryo vitrification (organised by Pierre Vanderzwalmen, Bregenz) 12:00 14:00 Lunch Basic aspects of cryobiology (Vanderzwalmen Pierre, IVF Centers Prof. Zech) Vitrification: Answers to FAQ (Vanderzwalmen Pierre, IVF Centers Prof. Zech) Immediate and longer term effects of vitrifiction on blastomere viability, cell division and embryo development (Chatzimeletiou Katarina, Papageorgiou General Hospital, Thessaloniki, Greece) Clinical application of oocyte and embryo vitrification in the closed system (Wirleitner Barbara, IVF Centers Prof. Zech) Vitrification of trophectoderm-biopsied blastocysts (Stecher Astrid, IVF Centers Prof. Zech) Hands-on workshop on aseptic Vitrisafe vitrification Closing remarks 10 14:00 18:00 3. Time-lapse and blastocyst culture for embryo selection (organised by Astrid Stecher, Bregenz) Time-lapse analysis: what is known from the literature? (Maximilian Schuff, IVF Centers Prof. Zech, Bregenz, Austria) Influence of culture conditions on embryo development up to the blastocyst stages (Astrid Stecher, IVF Centers Prof. Zech, Bregenz, Austria) Contribution of the paternal factors on embryo development (Pierre Vanderzwalmen, IVF Centers Prof. Zech, Bregenz, Austria) The role of lifestyle factors (Astrid Stecher & Johannes Wogatzky, IVF Centers Prof. Zech, Bregenz, Austria) Established criteria in embryo scoring vs. time-lapse analysis to the blastocyst stage. Let s ask the experts (Nicolas Zech, IVF Centers Prof. Zech, Bregenz, Austria) 14:00 17:00 4. RBM-online workshop (free): scientific writing workshop for aspiring authors (organised by Jacques Cohen, New York) Introduction: inspiration and need to publish Guidelines and ethics in experimentation and publication Types of publication and preparing a manuscript Submitting the manuscript online The peer review process Responding to referees comments Q&A 14:00 18: Sure user group meeting (free) (organised by Tony Gordon, BlueGnome Ltd) 24sure V3 protocol and BlueFuse Multi V3.0 software updates Karyomapping update User presentations 18:00 20:00 PGDIS board meeting 11 Thursday May 17, :15 Introduction and welcome Martin Reneé (Calgary, Canada), President PGDIS Zech Nicolas H (Bregenz, Austria), Congress President Handyside Alan H (London, UK), Chairman, Scientific Committee Plenary session (1) New developments in preconception testing and prenatal diagnosis Chaired by Simpson JL (Miami, FL, USA) & Kuliev A (Chicago, IL, USA) PL1 PL2 08:30 Preconception testing by next generation sequencing Kingsmore S (Kansas City, MO, USA) 09:15 Prenatal diagnosis in the era of the personal genome Vermeesch J (Leuven, Belgium) 10:00 10:30 Coffee Session (1) The polar bodies of the oocyte: insights into meiosis and maternal genetic defects Chaired by Rechitsky S (Chicago, USA) & Martin R (Calgary, Canada) S1 S2 S3 S4 10:30 Polar body based PGD for genetic and chromosomal disorders Kuliev A (Chicago, IL, USA) 11:00 Why are human eggs so often aneuploid? A novel hypothesis from chromosome cohesion Kudo N (London, UK) 11:30 Polar body biopsy and array CGH for aneuploidy in advanced maternal age Montag M (Heidelberg, Germany) 12:00 The use of polar bodies and cumulus cells to assess oocytes and select embryos Fragouli E (Oxford, UK) 12:30 14:00 Lunch Invited oral communications (1) Chaired by Griffin D (Canterbury, UK) & Thornhill A (London, UK) O1 O2 14:00 Polar body 1, polar body 2 and blastomere analysis in PGS treatment Fishel S, Cater E, Lynch C, Jenner L, Campbell A (Manchester & Nottingham, UK) 14:20 Altered morphokinetic parameters of embryos identified as aneuploid by single cell array CGH analysis at the 8-cell stage Davies S, Christopikou D, Tsorva E, Karagianni T, Mastrominas M, Handyside AH (Athens, Greece & Leeds, UK) 12 O3 O4 O5 O6 14:40 Aneuploidy screening reveals high incidence of abnormalities of chromosomes which are not involved in the rearrangements Beyazyurek C, Yapan C, Ekmekci GC, Yesil M, Altýn G, Yelke HK, Kahraman S (Istanbul, Turkey) 15:00 Preimplantation Genetic Diagnosis (PGD) for chromosomal rearrangements (CR) using arrays of comparative genome hybridization (acgh). Risk assessment depending on the type of CR, the maternal age and the sex of the carrier Jiménez-Macedo A, Garcia-Guixé E, Escudero T, Colls P, Munné S, Giménez C, Sandalinas M (Barcelona, Spain & Livingston, NJ, USA) 15:20 Determination of mutation loads in preimplantation embryos to assess the effectiveness of preimplantation genetic diagnosis (PGD) for mitochondrial DNA (mtdna) inherited disorders Irving L, Craven L, Alston C, Byerley S, Taylor RW, Herbert M, Turnbull DM (Newcastle upon Tyne, UK) 15:40 Homozygous mutations and haplotype backgrounds; implications for PGD Renwick P, Patel H, Khalaf Y, Al-Dabbous R, Ogilvie C (London, UK & Kuwait City, Kuwait) 16:00 16:30 Tea Advanced topics in clinical PGD (1) Chaired by Kahraman S (Istanbul, Turkey) & Hamamah S (Montpellier, France) S5 S6 S7 S8 S9 16:30 What about mitochondrial biopsy? Gianaroli L, Lang M, Romeo G, Luiselli D (Bologna, Italy) 16:55 Polar body analysis by array CGH and follow up at cleavage stages Christopikou D (Athens, Greece) 17:20 TBC Munné S (Livingstone, NJ, USA) 17:45 PGD for de novo mutations Rechitsky S (Chicago, IL, USA) 18:10 PGD and HLA matching: a clinical update Kahraman S (Istanbul, Turkey) 18:30 19:30 Poster session (1) 20:30 Invited speakers dinner 13 Friday May 18, 2012 Plenary session (2) From zygote to blastocyst: the establishment of cell lineages Chaired by Handyside AH (London, UK) PL3 PL4 08:30 Prepatterning in the mammalian embryo Zernica-Goetz M (Cambridge, UK) 09:15 The establishment of cell lineages in the human preimplantation embryo Van de Velde H (Brussels, Belgium) 10:00 10:30 Coffee Session (2) The cleavage and blastocyst stage embryo: the evolving genome Chaired by Wilton L (Melbourne, Australia) & Thornhill A (London, UK) S10 S11 S12 S13 S14 10:30 Cleavage stage and blastocyst biopsy Handyside AH (London, UK) 10:50 Chromosomal mosaicism in the cleavage stage embryo revisited Wilton L (Melbourne, Australia) 11:15 Chromosomal instability in the human preimplantation embryo Voet T (Leuven, Belgium & Cambridge, UK) 11:40 PGD for aneuploidy and translocation chromosome imbalance by cleavage stage biopsy Fiorentino F (Rome, Italy) 12:05 Blastocyst biopsy for aneuploidy screening Wells D (Oxford, UK) 12:30 14:00 Lunch Invited oral communications (2) Chaired by Fiorentino F (Rome, Italy) & Wells D (Oxford, UK) O7 O8 14:00 Assessment of 669 embryos and clinical outcome from 113 cycles using array CGH of blastomeres Veselá K, Horòák M, Horák J, Oráèová E, Hromadová L, Veselý J, Trávník P, Rubeš J (Brno, Czech Republic) 14:20 Accuracy rates in biopsies performed on day-3 and day-5 embryos using CGH array technology for PGS Mir P, Rodrigo L, Mateu E, Mercader A, Escrich L, Buendía P, Delgado A, Poo ME, Vera M, Simón C, Rubio C (Valencia, Spain) 14 O9 O10 O11 O12 14:40 Mosaicism in blastocyst stage embryos Barahona P, Traversa M, Leigh D, McArthur S (Sydney, Australia) 15:00 Use of next generation sequencing technology is feasible for current PGD with fresh embryo transfer Xu KP, Victor AR, Zhang CH, Jiang H, Li XC, Zhang XQ, Yang HM, Rosenwaks Z (New York, NY, USA & Shenzhen, China) 15:20 Blastocyst trophoderm cells screening by massively parallel sequencing for aneuploidy and imbalanced chromosomal arrangements detection Yin X, Tan K, Zhang C, Chen S, Zhang C, Pan X, Li X, Chen F, Jiang H, Lin G, Lu G, Zhang X (Shenzhen, Guangdong & Hunan, China) 15:40 Non-invasive prenatal diagnosis of congenital adrenal hyperplasia New MI, Lekarev O, Yuen T, Lo DYM (New York, NY, USA) 16:00 16:30 Tea Advanced topics in clinical PGD (2) Chaired
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